Pramudji Hastuti Pengarang apt. Maya Uzia Beandrade, M.Sc Pengarang

ABSTRACT Prevalence of metabolic syndrome varies depending on ethnicity and gender, indicating that it is associated with genetic factors. The occurrence of this disease is influenced not only by gene variations but also by gene promoters that can be activated or deactivated by environmental factors through epigenetic mechanisms. Epigenetics involves environmental factors that influence specific cells through DNA changes that modify gene expression in promoters. Through this mechanism, DNA methylation can alter metabolism and lead to the development metabolic diseases. Certain dietary components and physical activity can increase DNA methylation or demethylation in gene promoters, which affect the risk of disease or inhibit the disease. Understanding environmental risks for the development of metabolic syndrome through DNA methylation and demethylation is crucial for the therapy, diagnosis and prognosis of this disease through the selection of appropriate nutrition Keywords: Diet, DNA Methylation, Epigenetic, Histone, Metabolic Syndrome