Detail Cantuman

ABSTRACT
Prevalence of metabolic syndrome varies depending on ethnicity and gender, indicating that it is associated with
genetic factors. The occurrence of this disease is influenced not only by gene variations but also by gene promoters
that can be activated or deactivated by environmental factors through epigenetic mechanisms. Epigenetics involves
environmental factors that influence specific cells through DNA changes that modify gene expression in
promoters. Through this mechanism, DNA methylation can alter metabolism and lead to the development metabolic
diseases. Certain dietary components and physical activity can increase DNA methylation or demethylation
in gene promoters, which affect the risk of disease or inhibit the disease. Understanding environmental risks for the
development of metabolic syndrome through DNA methylation and demethylation is crucial for the therapy, diagnosis
and prognosis of this disease through the selection of appropriate nutrition

Keywords: Diet, DNA Methylation, Epigenetic, Histone, Metabolic Syndrome